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. 2011 Oct 1;22(19):3671–3683. doi: 10.1091/mbc.E11-04-0309

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© 2011 Aoh et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 9: — Possible model of the role of PKA in the acute phase of glucose starvation and the effect on adaptor localization. (A) In the presence of glucose, PKA directs the activation of an unknown factor (X). This factor is kept inactive by the presence of glucose. (B) On glucose starvation, the unknown factor becomes active and reduces levels of PI4P at the TGN and endosomes. (C) When PKA is inhibited, the unknown factor is not active, and the immediate response does not occur upon glucose starvation. Depletion of activity of the unknown factor levels after prolonged starvation also allows recovery of PI4P levels and adaptor re-recruitment.