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. 2011 Oct 1;22(19):3684–3698. doi: 10.1091/mbc.E11-04-0308

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© 2011 Fu et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 8: — Working model for a role of retrolinkin and endophilin A1 in BDNF–TrkB endocytic trafficking and downstream signaling pathways. TrkB receptors are activated upon binding to BDNF, and the internalization of BDNF–TrkB complex into endocytic vesicles is mediated by retrolinkin through unknown mechanisms. After TrkB-positive endocytic vesicles mature into APPL1 endosomes, endophilin A1 is recruited to these endosomes by retrolinkin, and then downstream effectors such as ERK1/2 are recruited to signaling endosomes for acute activation. EEN1, endophilin A1; RTLN, retrolinkin.