Table 1.
Patients with HIV-1 and Lyme neuroborreliosis co-infection; baseline data, clinical and laboratory characteristics
| Patient no. | Sex | Age | Years since HIV diagnosis | CD4 cell count (cells/μL) | Viral load at diagnosis of LNB (copies/mL) | Symptoms of LNB | CSF laboratory data |
Borrelia diagnosis | History of tick bite | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| nadir | at diagnosis of LNB | plasma | CSF | Mono-nuclear cells (cells/μL) | Albumin (mg/L) | |||||||
| 1 | m | 60 | 24 | 190 | 190 | 65,907 | 1,100,000 | radicular pain, cognitive impairment | 193 | 2790 | CSF Bb-antibodies + positive Bb antibody index | yes |
| 2 | m | 39 | 6 | 280 | 390 | 83,400 | 448,000 | hearing-loss, vertigo (pontine infarction) | 492 | 2860 | CSF Bb-antibodies + positive Bb antibody index | no |
| 3 | m | 62 | 6 | 180 | 320 | < 20 | 219 | dysgeusia, vertigo, incontinence, headache (normal pressure hydrocephalus) | 93 | 2000 | CSF Bb-antibodies + positive Bb antibody index | no |
| 4 | m | 50 | 5 | 180 | 450 | nd | nd | headache, facial palsy | 50 | 481 | CSF Bb IgG seroconversion | no |
CSF: cerebrospinal fluid; m: male; nd: no data; Bb: Borrelia burgdorferi. Reference values: CD4 cells > 500 cells/μL, CSF mononuclear cells < 5 cells/μL, CSF albumin < 420 mg/L.