Table 3.
Univariate Cox hazard regression analysis for prognostic factors
| subset | Adjusted Hazard ratio (95% confidence interval) |
P-value | |
|---|---|---|---|
| Gender | male/female | 0.031 (0.000-5.569) | 0.190 |
| Age | < 60/≥60 | 1.630 (0.564-4.716) | 0.367 |
| Smoking | nonsmoker/current smoker | 1.388 (0.306-6.297) | 0.671 |
| Tumor size | 0-3 cm/> 3 cm | 0.766 (0.239-2.455) | 0.654 |
| Histological classification | adenocarcinoma/SCC | 2.739 (0.781-9.604) | 0.115 |
| Invasion to lung membrane | Negative/positive | 1.000 (0.221-4.534) | 1.000 |
| Differentiation | Mod-well/poor | 0.757 (0.182-3.141) | 0.701 |
| Lymph node | Negative/positive | 1.279 (0.425-3.850) | 0.661 |
| Stage classification | stage I/stage II, III, IV | 1.001 (0.334-2.996) | 0.999 |
| Tumor miR-96 | High, > 6.45/low, < 6.45 | 9.637 (1.963-47.315) | 0.005 * |
| Tumor miR-182 | High, > 6.25/low, < 6.25 | 7.163 (1.597-32.138) | 0.010 * |
| Tumor miR-183 | High, > 4.44/low, < 4.44 | 8.616 (1.918-38.705) | 0.005* |
| Serum miR-96 | High, > 5.98/low, < 5.98 | 5.512 (1.219-24.915) | 0.027 * |
| Serum miR-182 | High, > 2.08/low, < 2.08 | 5.327 (1.181-24.030) | 0.030 * |
| Serum miR-183 | High, > 1.84/low, < 1.84 | 5.972 (1.289-27.658) | 0.022 * |
Univariate cox hazard regression analysis. *indicates a significant difference (P <0.05).