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. 2011 Sep 29;6(9):e25343. doi: 10.1371/journal.pone.0025343

Figure 3. Kin17 is associated with DNA damage in breast cells.

Figure 3

(A) Knockdown of kin17 increased DNA damage in MCF-10A and BT474 cells. (B) The cells were treated with ADM at the indicated concentrations for 24 hr, and analyzed using the comet assay kit. (C) Representative images of DNA damage in BT474 cells. The cells were transfected with siRNA_kin17 or treated with ADM (0.3 µg/ml) for 24 hr. Scale bars = 50 µm. (D) The effect of kin17 knockdown on the chemosensitivity to ADM in MCF-10A, BT474 and MDA-MB-231 cells (p<0.05). (E) The cells were treated with ADM at the indicated concentrations for 48 hr, and then kin17 expression was analyzed by western blot.