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. 2011 Sep 29;7(9):e1002297. doi: 10.1371/journal.pgen.1002297

Figure 2. Inter-conversion of new [PSI] strains.

Figure 2

(A) Infection by prion particles. [PSI] strains are represented by geometric shapes with black frames. Genetic backgrounds are in italic. Arrows indicate the direction of transmission and the outcome. “x” indicates [PSI] curing. (B) Transmission via mating and sporulation. [PSI] strains are transmitted to heterozygous backgrounds (represented by two-colored hexagons) by mating. The heterozygotes are then sporulated. When forming heterozygotes causes [PSI] curing of the diploids, the percentage of cured colonies is indicated. 21 =  N21L; 28 = R28P; 47 = Gi47. Prion strains are unambiguously determined by all strain typing methods shown in Figure 1 (see also Table 3 and Table 4).