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. 2011 Sep 29;7(9):e1002306. doi: 10.1371/journal.pgen.1002306

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Pincus et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A,D) Daily images of mir-246::GFP (A) or mir-239::GFP (D) expression patterns for two individuals, from day 3 to the last day of life are shown (top-to-bottom), straightened and pseudocolored as in Figure 2A. (B,E) Average mir-246::GFP (B) or mir-239::GFP (E) expression (measured as the 95^th percentile of whole-body intensity) versus time is shown for cohorts with different longevities. Shorter-lived animals have, in general, more rapidly declining levels of mir-246::GFP expression and slightly more rapidly increasing levels of mir-239::GFP. (C) The slope of a fit line to mir-246::GFP intensity between days 3 and 7 correlates with each animal's future longevity; R² = 0.20 (p<10⁻⁶; l.o.o. 0.18). Points corresponding to the individuals shown in panel A are in red and marked with arrowheads. (F) The slope of mir-239::GFP, days 3–7, anti-correlates with future longevity; R² = 0.10 (p<10⁻⁴; l.o.o. 0.070). Individuals from panel D are in red and marked with arrowheads. The use of the predictions from panels C and F as tests for actual above-average longevity (including sensitivity and specificity figures) are shown in Figure S2E and S2F.