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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Nat Neurosci. 2011 Sep 4;14(10):1237–1239. doi: 10.1038/nn.2920

Fig. 1. Visual stimulation induces histone mark modifications on specific CRE loci close to miR132 coding sequence and activates mature and primary miR132 expression.

Fig. 1

a) Ac(Lys9-14)H3 ChIP showed visually-induced H3 acetylation at the CRE loci upstream of miR132, miR212 and fos. * p<0.05.

b) p(Ser10)Ac(Lys14)H3 ChIP showed visually-induced H3 phosphoacetylation at the CRE sequences upstream of miR132 and fos, but not miR212.

c) Me2(Lys4)H3 ChIP showed visually-induced H3 dimethylation at the CRE sequence upstream of miR132 and fos, but not miR212.

d) Developmental expression of pri-miR132 and miR132 in the visual cortex of STR and DRB mice. Pri-miR132 (left) and miR132 (right) expression significantly increased with age in STR but not in DRB mice. * represents significant differences between STR and DRB.

e) DR3d decreased pri-miR132 (left) and miR132 (right) in visual cortex respect to age matched mice (P27 STR).

f) Visual stimulation after DR3d increased pri-miR132 (left) and miR132 (right) levels. Data are reported as mean ± SEM.