Table 1.
Proteins significantly increased in liver extracts from Ent hibernators
| GI | protein | Ent/SA | p-value | gene | species | function |
|---|---|---|---|---|---|---|
| 28872725 | proteasome 26S non-ATPase subunit 11 | 2.68 | 6.63E-03 | PSMD11 | H. sapiens | protein catabolism |
| 19527028 | high density lipoprotein binding protein | 2.08 | 9.62E-04 | HDLBP | M. musculus | cellular cholesterol homoeostasis |
| 52345385 | protein disulfide isomerase-related protein | 1.92 | 2.55E-06 | PDIA6 | R. norvegicus | protein folding |
| 34577110 | fructose-bisphosphate aldolase A | 1.85 | 2.57E-02 | ALDOA | H. sapiens | gluconeogenesis |
| 4507677 | tumor rejection antigen (gp96) 1 | 1.71 | 5.46E-23 | HSP90B1‡ | H. sapiens | protein folding |
| 4758950 | peptidylprolyl isomerase B, cyclophilin B | 1.68 | 9.20E-03 | PPIB | H. sapiens | protein folding |
| 16507237 | heat shock 70kDa protein 5 | 1.66 | 2.89E-18 | HSPA5‡ | H. sapiens | protein folding |
| 27807407 | ferritin, light polypeptide | 1.65 | 2.60E-03 | FTL | B. taurus | iron transport and storage |
| 27806321 | aldehyde dehydrogenase 1A1 | 1.64 | 6.57E-03 | ALDH1A1 | B. taurus | aldehyde metabolism |
| 9910128 | aldehyde dehydrogenase 9A1 | 1.57 | 9.21E-04 | ALDH9A1 | M. musculus | amino aldehyde metabolism |
| 32189392 | peroxiredoxin 2 | 1.55 | 1.31E-04 | PRDX2 | H. sapiens | oxidative stress protection |
| 11415030 | H4 histone family, member E | 1.51 | 1.52E-03 | HIST1H4J | H. sapiens | histone |
| 5453832 | oxygen regulated protein precursor | 1.49 | 1.05E-02 | HYOU1 | H. sapiens | protein folding |
| 6679687 | protein disulfide isomerase associated 3 | 1.47 | 2.53E-07 | PDIA3‡ | M. musculus | glycoprotein folding |
| 12083607 | ribosomal protein S14 | 1.46 | 2.43E-03 | RPS14 | R. norvegicus | ribosomal protein |
| 13384620 | heterogeneous nuclear ribonucleoprotein K | 1.40 | 3.78E-05 | hnRNPK‡ | M. musculus | mRNA metabolism |
| 5031751 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 | 1.38 | 6.55E-07 | HMGCS2‡ | H. sapiens | ketone body formation |
| 20849516 | similar to 60S ribosomal protein L12 | 1.35 | 2.21E-02 | RPL12 | M. musculus | ribosomal protein |
| 13386034 | ribosomal protein S13 | 1.35 | 8.02E-03 | RPS13 | M. musculus | ribosomal protein |
| 6680179 | hemoglobin Z, beta-like embryonic chain | 1.34 | 8.98E-03 | HBE1 | M. musculus | oxygen transport |
| 38090038 | similar to Rpl7a protein | 1.31 | 2.03E-02 | RPL7A | M. musculus | ribosomal protein |
| 16758398 | acyl-CoA synthetase long-chain 5 | 1.30 | 4.52E-05 | ACSL5 | R. norvegicus | lipid/fatty acid metabolism |
| 13540663 | betaine-homocysteine methyltransferase | 1.24 | 9.44E-04 | BHMT | R. norvegicus | methionine regeneration |
| 18677763 | hydroxyacyl-Coenzyme A dehydrogenase | 1.24 | 3.15E-06 | HADHA | R. norvegicus | fatty acid metabolism |
| 4503497 | enoyl-CoA hydratase/3-hydroxyacyl CoA DH | 1.24 | 5.13E-02 | EHHADH | H. sapiens | lipid/fatty acid metabolism |
| 16933546 | ribosomal protein P0 | 1.20 | 4.19E-02 | RPLP0 | H. sapiens | ribosomal protein |
| 22122797 | 3-ketoacyl-CoA thiolase B | 1.15 | 2.21E-04 | ACAA1 | M. musculus | lipid/fatty acid metabolism |
Proteins are sorted by fold change, Ent>SA;
‡
previously found by DiGE