Table 2.
Proteins significantly decreased in liver extracts from Ent ground squirrels
| GI | protein | SA/Ent | p-value | gene | species | function |
|---|---|---|---|---|---|---|
| 29293809 | ATP citrate lyase | 6.67 | 2.24E-51 | ACLY‡ | M. musculus | lipid biosynthesis |
| 41872631 | fatty acid synthase | 5.82 | 9.63E-03 | FASN | H. sapiens | fatty acid biosynthesis |
| 21614513 | formyltetrahydrofolate dehydrogenase isoform a | 2.93 | 3.12E-03 | ALDH1L1‡ | H. sapiens | biosynthetic FTHF metabolism |
| 4557585 | fatty acid binding protein 7, brain | 2.16 | 7.48E-08 | FABP7‡ | H. sapiens | fatty acid transport and metabolism |
| 29789000 | succinate-CoA ligase, GDP-forming, beta | 1.89 | 1.38E-03 | SUCLG2‡ | H. sapiens | TCA cycle |
| 6980970 | glutamate oxaloacetate transaminase 1 | 1.86 | 2.23E-02 | GOT1‡ | R. norvegicus | amino acid metabolism; urea cycle |
| 34869518 | pyruvate dehydrogenase (lipoamide) beta | 1.81 | 7.66E-03 | PDHB‡ | R. norvegicus | glycolysis |
| 16758348 | peroxiredoxin 6 | 1.79 | 2.25E-04 | PRDX6 | R. norvegicus | lipid catabolism; response to oxidative stress; redox |
| 8393215 | cystathionine gamma-lyase | 1.76 | 2.71E-03 | CTH | R. norvegicus | cysteine and glutathione biosynthesis |
| 21313536 | dihydrolipoamide S-succinyltransferase (E2) | 1.75 | 4.51E-02 | DLST‡ | M. musculus | TCA cycle |
| 16758920 | cullin-associated and neddylation-dissociated 1 | 1.69 | 2.27E-02 | CAND1 | R. norvegicus | protein ubiquitination |
| 21312260 | aldehyde dehydrogenase 1 family, member B1 | 1.68 | 4.26E-40 | ALDH1B1‡ | M. musculus | carbohydrate metabolism |
| 20070418 | aldehyde dehydrogenase family 7, member A1 | 1.67 | 2.99E-03 | ALDH7A1‡ | M. musculus | detoxification |
| 6753272 | catalase | 1.65 | 7.96E-44 | CAT‡ | M. musculus | response to oxidative stress |
| 47522786 | UDP glucose pyrophosphorylase | 1.47 | 9.34E-04 | UGP2 | S. scrofa | glycogen synthesis |
| 13699868 | methylenetetrahydrofolate dehydrogenase 1 | 1.47 | 1.78E-02 | MTHFD1‡ | H. sapiens | amino acid metabolism, one carbon pool/folate |
| 14269572 | heat-responsive protein 12 | 1.44 | 6.00E-03 | HRSP12 | R. norvegicus | regulation of translational termination |
| 51705066 | carbamoyl-phosphate synthetase 1 | 1.43 | 8.38E-24 | CPS1 | M. musculus | urea cycle (rate limiting) |
| 8659555 | aconitase 1 | 1.40 | 1.59E-02 | ACO1 | H. sapiens | TCA cycle and iron homeostasis |
| 19526790 | methionine adenosyltransferase I, alpha | 1.37 | 3.00E-02 | MAT1A | M. musculus | S-adenosylmethionine biosynthesis |
| 19743875 | fumarate hydratase precursor | 1.36 | 4.58E-05 | FH | H. sapiens | TCA cycle |
| 11095441 | aldehyde dehydrogenase 6A1 precursor | 1.36 | 3.34E-07 | ALDH6A1 | H. sapiens | valine and pyrimidine catabolism |
| 11068137 | hydroxyacid oxidase 1 | 1.34 | 9.01E-04 | HAO1 | H. sapiens | fatty acid oxidation (dietary) |
| 34858436 | prohibitin-2 | 1.33 | 6.09E-03 | PHB2 | R. norvegicus | protein chaperone;mitochondrial integrity |
| 47522692 | long-chain acyl-CoA dehydrogenase | 1.31 | 3.18E-04 | ACADL | S. scrofa | fatty acid metabolic process |
| 27806831 | nicotinamide nucleotide transhydrogenase | 1.30 | 1.82E-03 | NNT | B. taurus | electron transport/TCA cycle |
| 47522912 | arginase I | 1.30 | 3.48E-02 | ARG1‡ | S. scrofa | amino acid metabolism; urea cycle |
| 4503301 | 2,4-dienoyl CoA reductase 1 precursor | 1.29 | 5.44E-03 | DECR1 | H. sapiens | metabolism (lipid and lipoprotein, unsat'd fa) |
| 31980648 | ATP synthase, mitochondrial F1 cplx, beta | 1.28 | 2.36E-02 | ATP5B‡ | M. musculus | ATP syntheis |
| 15100179 | malate dehydrogenase 1, NAD (soluble) | 1.26 | 1.58E-02 | MDH1‡ | R. norvegicus | TCA cycle, malate-asp shuttle |
| 21313272 | phosphogluconate dehydrogenase | 1.25 | 3.37E-03 | PGD | M. musculus | pentose phosphate; CHO metabolism |
| 6678359 | transketolase | 1.22 | 3.80E-03 | TKT‡ | M. musculus | pentose phosphate; CHO metabolism |
| 5174429 | acetyl-coenzyme A acyltransferase 2 | 1.19 | 3.38E-10 | ACAA2 | H. sapiens | fatty acid metabolism; cholesterol biosynthesis |
| 27807237 | ATP synthase, mitochondrial F1 cplx, alpha | 1.15 | 1.01E-03 | ATP5A1 | B. taurus | ATP synthesis |
Proteins are sorted by fold change, SA>Ent,
abbreviations used: cplx, complex; DH, dehydrogenase;CHO, carbohydrate; unsat'd, unsaturated
‡
previously found by DiGE