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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Pharmacol Biochem Behav. 2011 Aug 22;100(1):174–179. doi: 10.1016/j.pbb.2011.08.013

Table 1.

IC50 values for decrease in planarian motility and solubility parameters for the tested γ-lactones and related compounds.

Compound IC50 (μM ± s.e.m.1) logP Water solubility (mM)
γ-Valerolactone NI 0.603 251
γ-Hexalactone NI 0.981 76
γ-Heptalactone NI 1.335 22
γ-Octalactone 426 ± 438 1.668 7
γ-Nonalactone 181 ± 18 1.985 2
γ-Decalactone 43 ± 5 2.289 0.6
γ-Dodecalactone 146 ± 25 2.861 0.057
Parthenolide 105 ± 52 1.743 0.027
Costunolide 233 ± 132 2.826 0.004
Santonin 250 ± 312 1.598 0.285
β-Eudesmol 3 ± 0.72 3.475 0.062

This table shows the IC50 values for decrease in planarian motility induced by the tested γ-lactones, as obtained from fitting the data in Figure 3 to equation 1. NI = No inhibition of movement.

1

Standard Error of the Mean.