Table 2.
Effect of the tested γ-lactones on the motility decrease induced by 200 μM cocaine.
| Compounds tested | Fraction of control ± s.e.m1 | Number of replicates | P-value |
|---|---|---|---|
| Valerolactone (205 μM) | 0.90 ± 0.31 | 18 | 0.1902 |
| Cocaine (200 μM) | 0.60 ± 0.34 | 0.000013 | |
| Cocaine (200 μM) + Valerolactone (205 μM) | 0.55 ± 0.24 | 0.6244 | |
|
| |||
| Hexalactone (195 μM) | 0.80 ± 0.19 | 11 | 0.0802 |
| Cocaine (200 μM) | 0.49 ± 0.15 | 0.0000073 | |
| Cocaine (200 μM) + Hexalactone (195 μM) | 0.76 ± 0.21 | 0.1364 | |
|
| |||
| Heptalactone (100 μM) | 0.93 ± 0.18 | 8 | 0.4062 |
| Cocaine (200 μM) | 0.48 ± 0.17 | 0.000033 | |
| Cocaine (200 μM) + Heptalactone (100 μM) | 0.46 ± 0.17 | 0.8234 | |
|
| |||
| Octalactone (100 μM) | 0.96 ± 0.18 | 8 | 0.5942 |
| Cocaine (200 μM) | 0.49 ± 0.18 | 0.000033 | |
| Cocaine (200 μM) + Octalactone (100 μM) | 0.46 ± 0.12 | 0.8034 | |
|
| |||
| Nonalactone (51 μM) | 0.96 ± 0.17 | 12 | 0.8212 |
| Cocaine (200 μM) | 0.49 ± 0.14 | 0.00000013 | |
| Cocaine (200 μM) + Nonalactone (51 μM) | 0.88 ± 0.13 | 0.000354 | |
|
| |||
| Decalactone (10 μM) | 1.13 ± 0.15 | 12 | 0.1202 |
| Cocaine (200 μM) | 0.46 ± 0.17 | 0.000053 | |
| Cocaine (200 μM) + Decalactone (10 μM) | 0.46 ± 0.14 | 0.7704 | |
|
| |||
| Dodecalactone (7 μM) | 0.91 ± 0.18 | 6 | 0.2852 |
| Cocaine (200 μM) | 0.64 ± 0.21 | 0.0103 | |
| Cocaine (200 μM) + Dodecalactone (7 μM) | 0.81 ± 0.23 | 0.3494 | |
This table shows the effect of the experimental compounds on planarian motility, as indicated. The γ-lactones were tested at concentrations in which they have no effect on planarian motility.
1
Standard Error of the Mean.
2,3
Compared to control worms (2-tailed t-test).
4
Compared to 200 μM cocaine-exposed worms (2-tailed t-test).