Table 2.
Analog | Kd (nM) | Fold Loss | ΔΔGbind (kcal/mol) | |
---|---|---|---|---|
c-di-GMP | 2.2 ± 0.2a,b | - | - | |
| ||||
Base | c-di-IMP | 4.1 ± 0.4 | 1.9 | 0.4 |
c-c7-GMP | 33.0 ± 2.6 | 15.0 | 1.6 | |
c-di-c7GMP | 3500 ± 630 | 1600 | 4.4 | |
c-GMP-AMP | 271.1 ± 47.1 | 120 | 2.8 | |
c-di-AMP | ≥ 30,000 | ≥ 13,000 | ≥ 5.6 | |
c-N1mG-GMP | 160 ± 14 | 72 | 2.5 | |
| ||||
Ribose | c-di-dGMP | 11 ± 1.2 | 5.0 | 0.9 |
c-di-2’F-GMP | 5.8 ± 1.0 | 2.6 | 0.6 | |
c-di-2’OMe-GMP | 4.3 ± 0.7b | 2.0 | 0.4 | |
| ||||
Phosphate | c-(RpRp)-di-Gps | 3.6 ± 0.6 | 1.6 | 0.3 |
c-(RpSp)-di-Gps | 4.0 ± 0.8 | 1.8 | 0.4 |
Measured by direct binding.
Values previously reported43.