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Susceptibility breakpoints and chromosomal mutations associated with drug resistance
| Drug | Current breakpoint (mg/L) | Proposed breakpoint (mg/L) | Chromosomal mutations associated with resistance |
|---|---|---|---|
| Rifampin | 1 | 0.0625 | rpoB |
| Isoniazid | 0.2/1.0 | 0.03/0.125 | katC, inhA, oxyR, ahpC, furA |
| Streptomycin | 5 | - | rrs, rpsL |
| Pyrazinamide | 100 | 50 | pncA |
| Ethambutol | 5.0/7.5 | 4 | embB |
| Moxifloxacin | 1 | 1 | gyrB |
