Table I.
Characteristics of Unexplained Stillbirth Cases by Wigglesworth and Aberdeen Criteria.
| Wigglesworth (W) and Aberdeen (A) Classification& | Case Number | Gestational Age, weeks | Fetal Weight, grams | Placental Pathology | Maternal Comorbidities or Incidental Conditions |
|---|---|---|---|---|---|
| #Appropriate for Gestational Age Growth (>10 | |||||
|
| |||||
| W2A5 | 36 | 35 and 1/7 | 2160 | Unremarkable | Preeclampsia, Prior stillbirth |
|
| |||||
| W2A8 | 49 | 40 and 1/7 | 3400 | Abruptio placenta, Umbilical vein thrombosis | None |
|
| |||||
| W2A9 | 4 | 31 and 5/7 | 1700 | Retroplacental hematoma | None |
|
| |||||
| W2A15 | 8 | 38 and 5/7 | 3700 | Chorioamnionitis, Multiple infarcts | Type I IDDM |
| 19 | 36 and 3/7 | 2910 | Fibrosis, Multiple infarcts | Type II IDDM | |
|
| |||||
| W2A16 | 37 | 33 and 5/7 | 2035 | Unremarkable | Group B strep positive |
|
| |||||
| W2A20 | 9 | 37 and 2/7 | 3550 | Chorioamnionitis | None |
| 23 | 40 and 6/7 | 3700 | Umbilical vein calcium deposits | MTHFR (heterozygote) | |
| 30 | 38 and 0/7 | 3780 | Fibrosis, Multiple infarcts | Gestational diabetes (A1) | |
| 33 | 40 and 0/7 | 3460 | Unremarkable | None | |
| 43 | 37 and 2/7 | 2600 | Unremarkable | None | |
| 50 | 40 and 4/7 | 3900 | Unremarkable | None | |
| 51 | 38 and 2/7 | 2610 | Unremarkable | None | |
|
| |||||
| W2A21 | 1 | 32 and 3/7 | 1800 | Vascular maldevelopment | None |
| 3 | 36 and 5/7 | 2110 | Chorioamnionitis | None | |
| 46 | 34 and 0/7 | 1800 | Chorioamnionitis, Multiple infarcts | None | |
| 48 | 34 and 3/7 | 2000 | Chorioamnionitis, Multiple infarcts | None | |
|
| |||||
| #Small for Gestational Age (Growth %) | |||||
|
| |||||
| W2A5 | 6 | 34 and 0/7 | 1210 (<3rd%) | Multiple infarcts | Preeclampsia |
| 16 | 26 and 0/7 | 580 (<10th%) | Retroplacental hematoma, Mulitple infarcts | Preeclampsia, factor V Leiden (heterozygote) | |
| 25 | 24 and 6/7 | 325 (<3rd%) | Chorioamnionits | Preeclampsia | |
|
| |||||
| W2A8 | 15 | 35 and 4/7 | 1635 (<5th%) | Abruptio placenta, Multiple infarcts | Gestational hypertension |
|
| |||||
| W2A16 | 21 | 32 and 0/7 | 950 (<3rd%) | Chorioamnionitis | IVF pregnancy, Group B strep positive |
| 44 | 38 and 4/7 | 2450 (<10th%) | Unremarkable | Group B strep positive | |
|
| |||||
| W2A20 | 42 | 41 and 1/7 | 2670 (<3rd%) | Multiple infarcts | None |
|
| |||||
| W2A21 | 11 | 28 and 3/7 | 665 (<5th%) | Multiple infarcts | Prior stillbirth |
| 18 | 40 and 0/7 | 2300 (<3rd%) | Chorioamnionitis | None | |
| 31 | 24 and 0/7 | 485 (<3rd%) | Unremarkable | None | |
| 40 | 32 and 0/7 | 910 (<3rd%) | Chorioamnionitis | None | |
| 45 | 28 and 3/7 | 680 (<10th%) | Unremarkable | None | |
Wigglesworth (W) and Aberdeen (A) classifications were employed as previously described and recently reassessed (Refs 10, 21). W2 in the extended Wigglesworth classification refers to unexplained antepartum fetal death (by contrast a live born infant which demises due to issues which arise during the antepartum interval would be coded W6). Subsequent Aberdeen classifications are: A5: Preeclampsia; A8: Abruptio placenta; A9: Antepartum hemorrhage of uncertain origins; A15: Other maternal disorder; A16: Maternal infection (asymptomatic); A20: Unexplained, ≥2500 grams; A21: Unexplained, <2500 grams.
Cases were further divided by virtue of fetal growth, into appropriate for gestational age (AGA) and small for gestational age (SGA) by previously defined criteria (29). For all SGA (<10th%), the centiles at <10th, <5th, and <3rd are as noted in column 4.