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Inhibition of varenicline (3 mg/kg, IP) induced improvement of P20-N40 inhibition by DHβE (1 μl of 27 nM, ICV). The first five time points (baseline) refer to baseline recordings obtained prior to drug injection. Injection of the α4β2 antagonist DHβE (dashed line) occurred 20 minutes prior to injection of varenicline (dotted line). (●) Represent conditioning amplitude values and (Δ) represent the test amplitude values at each time point. Data are mean ± SEM; n = 10.
