Table 1.
Treatment | Dead cells (%) | ||
---|---|---|---|
OS-II (n = 10) | OS-III (n = 12) | MG-63 | |
Control | 19.25 ± 2.52 | 27.63 ± 3.40* | 25.38 ± 3.15 |
BQ788 (1 μmol/L) | 18.33 ± 2.24‡,§,∥,#,¶ | 25.92 ± 3.16‡,§,∥,#,¶,* | 22.84 ± 2.09 |
BQ123 (1 μmol/L) | 12.89 ± 1.57†,§,∥,# | 15.03 ± 2.26†,§,∥,# | 17.9 2± 1.63 |
ET-1 (10 pmol/L) | 24.95 ± 3.63†,‡,∥,#,¶ | 35.48 ± 4.75†,‡,∥,#,¶,* | 32.35 ± 4.26 |
ET-1 (100 pmol/L) | 37.82 ± 4.97†,‡,§,#,¶ | 46.25 ± 5.04†,‡,§,#,¶ | 43.86 ± 5.75 |
ET-1 (100 pmol/L) + BQ123 (100 pmol/L) | 18.85 ± 2.13‡,§,∥,f | 26.80 ± 3.36‡,§,∥,f,* | 25.34 ± 2.81 |
ET-1 (100 pmol/L) + BQ123 (1 μmol/L) | 14.75 ± 1.51†,§,∥,# | 17.80 ± 2.03†,§,∥,# | 18.34 ± 1.75 |
†p < 0.05 compared with control; ‡p < 0.05 compared with BQ123 (1 μmol/L); §p < 0.05 compared with ET-1 (10 pmol/L); ∥p < 0.05 compared with ET-1 (100 pmol/L); #p < 0.05 compared with ET-1 (100 pmol/L) + BQ123 (100 pmol/L); ¶p < 0.05 compared with ET-1 (100 pmol/L) + BQ123 (1 μmol/L); *p < 0.05 compared with OS-II group; OS-II = Stage II osteosarcoma; OS-III = Stage III osteosarcoma.