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. 2011 Jun 22;26(10):2523–2536. doi: 10.1002/jbmr.450

Fig. 1.

Fig. 1

Reduced ETAR expression and trabecular bone volume in KO mouse tibias. (A) Tibias of WT and KO mice were analyzed for ETAR protein expression by immunohistochemistry. In ×100 magnification images, primary (blue) and secondary (yellow) spongiosae are indicated. Inset boxes correspond to ×200 magnification images. Arrows indicate osteoblasts, and triangles indicate osteocytes. M = bone matrix. (B) µCT images showing reconstructions of proximal tibia trabecular bone demonstrating lower trabecular bone volume in KO mice.