Table 1.
Effect of Aβ on cell death, apoptosis and free radical generation in the absence or presence of different concentrations of walnut extract (WE) in PC12 cells
| Aβ-induced changes | Aβ (50 μM) | Aβ (75 μM) | ||||
|---|---|---|---|---|---|---|
| No WE | +WE (2 μg GAE) | +WE (4 μg GAE) | Control (No WE) | +WE (2 μg GAE) | +WE (4 μg GAE) | |
| LDH release (increase in membrane damage) | 251.8% | 155.4% | 88.7% | 357.3% | 166.2% | 140.9% |
| MTT (decrease in cell viability) | −60.0% | −46.8% | −41.2% | −62.1% | −47.8% | −45.1% |
| Apoptosis (fold increase in DNA fragmentation) | 47.1 | 5.2 | 5.1 | 64.9 | 7.0 | 7.6 |
| ROS (increase in free radical generation) | 79.1% | 25.5% | 12.5% | 106% | 44.9% | 27.9% |
The effect of Aβ on LDH release, MTT reduction, DNA fragmentation and ROS levels in the absence or presence of walnut extract is calculated in comparison to controls (no Aβ)