Table 1.
Anti-HIV-1 NL4-3 and HIV-1 RTMDR results of seco-DCP analogues (8–15, 29–31, and 34–37) in TZM-bl cells a
| Compd | CC50 (μM) | HIV-1NL4-3 | RTMDR | ||
|---|---|---|---|---|---|
| EC50 (μM) | TI | EC50 (μM) | TI | ||
| 8 | >48.29 | 27.45 | >1.76 | 7.91 | >6.11 |
| 9 | >40.64 | 30.69 | >1.32 | 9.70 | >4.19 |
| 10 | >46.68 | 3.69 | >12.6 | 2.26 | >20.5 |
| 11 | 23.14 | 16.67 | 1.39 | 5.18 | 4.47 |
| 12 | >45.23 | 0.47 | >95.95 | 0.88 | >51.37 |
| 13 | 16.94 | 2.24 | 7.55 | 1.52 | 11.12 |
| 14 | 37.08 | 1.11 | 33.0 | 0.94 | 39.5 |
| 15 | >37.35 | 31.28 | >1.33 | 25.90 | >1.44 |
| 29 | >50 | >50 | NS | 23.3 | >2.14 |
| 30 | 36.72 | 18.36 | 2 | 9.28 | 3.96 |
| 31 | >47 | 2.5 | >18.75 | 1.49 | >31.45 |
| 34 | >22.00 | >22.00 | NS | 16.94 | 1.30 |
| 35 | >22.30 | 16.72 | >1.33 | 16.28 | >1.37 |
| 36 | >21.62 | 19.03 | >1.14 | 16.0 | >1.36 |
| 37 | >20.51 | >20.51 | NS | >20.51 | NS |
| 4 | 14.25 | 0.12 | 118.75 | 0.20 | 71.25 |
| 7 | 17.27 | 0.5 | 34.54 | 1.89 | 9.13 |
a
All data presented in this table were averaged from at least three independent experiments. Cytotoxicity was determined using a Promega CytoTox-Glo assay kit.
NS: no suppression at the highest tested concentration (20 μM).