Table 2.
Anti-HIV-1 NL4-3 data of seco-DCP and -DCK analogues (16–28, 32, and 33) in TZM-bl cells a
| Compd | CC50 (μM) | HIV-1NL4-3 | |
|---|---|---|---|
| EC50 (μM) | TI | ||
| 16 | - | - | NS |
| 17 | >40.69 | 11.00 | 3.70 |
| 18 | >40.69 | 1.26 | 32.29 |
| 19 | >40.69 | 1.93 | 21.08 |
| 20 | NS | ||
| 21 | >38.79 | 2.41 | >16.09 |
| 22 | >38.42 | 1.63 | 23.57 |
| 23 | >36.46 | 0.93 | 39.20 |
| 24 | >39.64 | 1.92 | 20.65 |
| 25 | >36.32 | 22.18 | 1.64 |
| 26 | >34.81 | 18.45 | 1.87 |
| 27 | - | - | NS |
| 28 | - | - | NS |
| 32 | 32.62 | 1.53 | 21.32 |
| 33 | 6.3 | 0.56 | 11.25 |
| 4 | 14.25 | 0.12 | 118.75 |
| 7 | 17.27 | 0.5 | 34.54 |
a
All data presented in this table were averaged from at least three independent experiments. Cytotoxicity was determined using a Promega CytoTox-Glo™ assay kit. NS: no suppression at the highest tested concentration (20 μM).