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. Author manuscript; available in PMC: 2012 Sep 27.
Published in final edited form as: Circulation. 2011 Sep 6;124(13):1452–1460. doi: 10.1161/CIRCULATIONAHA.111.032920

Table 3.

Independent predictors of increased TRV by multiple linear regression analysis.

N = 320 Beta (95% CI) [Estimated increase in TRV in m/sec] P
Hemolytic component (1 SD increase) 0.09 (0.06, 0.12) <0.0001
LV lateral E/e′ ratio (natural log increase) 0.19 (0.09, 0.29) 0.0001
BUN (natural log increase) 0.10 (0.05, 0.16) 0.0002
Serum erythropoietin (natural log increase) 0.07 (0.03, 0.11) 0.002

Variables entered into model were: age, systolic blood pressure, pulse pressure, oxygen saturation, hemoglobin, erythropoietin, BUN, creatinine, hemolytic component, left atrial volume index, left ventricular mass index, LV lateral E/e′.

Eleven outliers were removed, R-square = 0.25

Each of the following variables could substitute for hemolytic component in the multiple linear regression model as follows (beta and 95% CI are given):

Total bilirubin (natural log): N=373, beta = 0.06, 95% CI = 0.02, 0.11.

Aspartate aminotransferase* (natural log): N=368, beta = 0.07, 95% CI = 0.01, 0.13.

Reticulocyte % (square root): N=350, beta = 0.05, 95% CI = 0.02, 0.09.

Lactate dehydrogenase* (natural log): N=348, beta = 0.10, 95% CI = 0.04, 0.17

*

site adjusted