. Author manuscript; available in PMC: 2012 Oct 1.

Published in final edited form as: Am J Kidney Dis. 2011 Aug 24;58(4):666–677. doi: 10.1053/j.ajkd.2011.05.032

Table 4.

Treatment of Membranous Nephropathy

Risk Level	Approach	Immunosuppression
Low Risk (proteinuria <4 g/d, normal kidney function)	General measures^*	None
Moderate risk (proteinuria 4- 8 g/d, normal kidney function)	General measures; observe for 6 mo	Cyclophosphamide + steroid (alternative is cyclosporin / tacrolimus)
High risk (proteinuria >8 g/d +/− reduced kidney function)	General measures; consider early immunosuppression	Cyclophosphamide + steroid (alternative is Cyclosporin / tacrolimus)

see general measures for treatment of nephrotic syndrome.