Table 2.
COPD patients (n=60) | Healthy controls (n=43) | p | |||
---|---|---|---|---|---|
Mean ± SD or median [IQR] | Range | Mean ± SD or median [IQR] | Range | ||
Maximum level of thrombin, nM | 407 ± 76 | 457–571 | 317 ± 62 | 217–479 | <0.000001 |
Time to maximum level of thrombin, s | 453 ± 47 | 346–561 | 519 ± 56 | 397–613 | <0.000001 |
Total thrombin (area under the curve), μM · s | 92.7 ± 23.0 | 54.3–154.3 | 81.0 ± 16.5 | 55.7–129.5 | 0.003 |
Time to 10 nM of thrombin, s | 197.5 ± 30 | 132–264 | 236 ± 41 | 146–319 | <0.000001 |
Maximum rate of thrombin, nM · s−1 | 2.82 ± 0.64 | 1.72–5.09 | 1.93 ± 0.51 | 1.22–3.58 | <0.000001 |
Time to maximum rate of thrombin, s | 363 ± 38 | 279–450 | 413 ± 45 | 317–491 | <0.000001 |
COPD, chronic obstructive pulmonary disease; IQR, interquartile range; SD, standard deviation.
Normally distributed continuous variables were compared using t test for independent variables; otherwise Mann-Whitney U-test was employed.