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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Thromb Res. 2011 May 31;128(4):e24–e28. doi: 10.1016/j.thromres.2011.05.004

Table 2.

Thrombin generation in COPD patients and healthy controls.

COPD patients (n=60) Healthy controls (n=43) p
Mean ± SD or median [IQR] Range Mean ± SD or median [IQR] Range
Maximum level of thrombin, nM 407 ± 76 457–571 317 ± 62 217–479 <0.000001
Time to maximum level of thrombin, s 453 ± 47 346–561 519 ± 56 397–613 <0.000001
Total thrombin (area under the curve), μM · s 92.7 ± 23.0 54.3–154.3 81.0 ± 16.5 55.7–129.5 0.003
Time to 10 nM of thrombin, s 197.5 ± 30 132–264 236 ± 41 146–319 <0.000001
Maximum rate of thrombin, nM · s−1 2.82 ± 0.64 1.72–5.09 1.93 ± 0.51 1.22–3.58 <0.000001
Time to maximum rate of thrombin, s 363 ± 38 279–450 413 ± 45 317–491 <0.000001

COPD, chronic obstructive pulmonary disease; IQR, interquartile range; SD, standard deviation.

Normally distributed continuous variables were compared using t test for independent variables; otherwise Mann-Whitney U-test was employed.