Table 3.
Total Circulating 25(OH)D Concentration (nmoL) during Pregnancy by Treatment Group
| Measure | 400 IU Group | 2000 IU Group | 4000 IU Group | p-value |
|---|---|---|---|---|
| 25(OH)D at baseline, Mean ± SD | 61.6 ± 27.1 | 58.3 ± 22.3 | 58.2 ± 21.8 | 0.5 |
| (Range) | (6.0 – 172.5) | (14.0 – 115.3) | (11.8 – 109.3) | |
|
| ||||
| 25(OH)D 1 month before delivery | ||||
| Mean ± SD | 79.4 ± 34.3 | 105.4 ± 35.7 | 118.5 ± 34.9 | <0.0001 |
| (Range) | (16.0 – 193.0) | (17.3 – 176) | (26.3 – 243.5) | |
|
| ||||
| 25(OH)D at delivery, Mean ± SD | 78.9 ± 36.5 | 98.3 ± 34.2 | 111.0 ± 40.4 | <0.0001 |
| (Range) | (12.5 – 159.5) | 18.0 – 177.0 | 25.0 – 251.0 | |
|
| ||||
| 25(OH)D, 20–36 weeks,1 Mean ± SD | 79.1 ± 29.5 | 94.4 ± 26.1 | 110.8 ± 28.3 | <0.0001 |
| (Range) | (17.1 – 162.3) | (16.7 – 149.1) | (26.5 – 212.3) | |
|
| ||||
| Achieved 25(OH)D Level ≥80 nmoL at 1 month prior to delivery, N (%) | 51 (50.0) | 82 (73.9) | 91 (82.0) | <0.0001 |
|
| ||||
| Achieved 25(OH)D Level ≥80 nmoL at delivery, N (%) | 43 (50.0) | 63 (70.8) | 68 (82.0) | <0.0001 |
|
| ||||
| Achieved 25(OH)D Level ≥80 nmoL at 1 month prior to delivery or at delivery, N (%) | 57 (52.3) | 93 (79.5) | 94 (83.9) | <0.0001 |
|
| ||||
| Infant birth 25(OH)D, Mean ± SD | 18.2 ± 10.1 | 22.8 ± 9.8 | 26.5 ± 10.3 | <0.0001 |
| (Range) | (2.4 – 48.4) | (3.6 – 47.9) | (2.4 – 52.0) | |