Table 3.
Expression of nuclear receptor target genes in DA and DA.ACI(Cia25) congenics§.
| Gene Symbol | Gene | Accession | Fold difference¶ | P-value* |
|---|---|---|---|---|
| Pparg-induced genes (selected from a list of 29) | up in Cia25 | |||
| Pck1 | phosphoenolpyruvate carboxykinase 1 | NM_198780.2 | 9.99 | 0.000004 |
| Plin | perilipin | NM_013094.1 | 6.45 | 0.000000 |
| Cidea | cell death-inducing DNA fragmentation factor | XM_214551.3 | 6.30 | 0.000004 |
| Scd1 | stearoyl-Coenzyme A desaturase 1 | NM_139192.1 | 5.25 | 0.0001 |
| Adipoq | adiponectin, C1Q and collagen domain containing | NM_144744.1 | 5.16 | 0.000006 |
| Pparg | nuclear receptor subfamily 1 (Nr1c3) | NM_013124.1 | 4.59 | 0.000005 |
| Rev-erba | nuclear receptor subfamily 1 (Nr1d1) | NM_145775.1 | 4.11 | 0.0003 |
| Cyp27a1 | cytochrome P450, family 27, subfamily a, polypeptide 1 | XM_579715.1 | 2.64 | 0.00003 |
| Cd36 | cd36 antigen | NM_031561.2 | 2.36 | 0.0001 |
| Lxra | liver X receptor alpha, (Nr1h3) | NM_031627 | 1.60 | 0.002 |
| Pparg-repressed genes | up in DA | |||
| Col5a2 | collagen, type V, alpha 2 | NM_053488.1 | 2.53 | 0.00002 |
| Col3a1 | collagen, type III, alpha 1 | NM_032085.1 | 2.47 | 0.00002 |
| Ralgds | ral guanine nucleotide dissociation stimulator | NM_001191753 | 1.56 | 0.003 |
| Pdgfra | platelet derived growth factor receptor | NM_012802.1 | 1.52 | 0.004 |
| Rora-induced genes | up in Cia25 | |||
| Slc2a4 | solute carrier family 2, member 4 (Glut4) | NM_012751.1 | 5.92 | 0.0000004 |
| Scd1 | stearoyl-Coenzyme A desaturase 1 | NM_139192.1 | 5.25 | 0.0001 |
| Srebf1 | sterol regulatory element binding factor 1 | XM_213329.3 | 4.34 | 0.000001 |
| Rev-erba | nuclear receptor subfamily 1 (Nr1d1) | NM_145775.1 | 4.11 | 0.0003 |
| Cnn1 | calponin 1, basic, smooth muscle | NM_031747.1 | 3.04 | 0.001 |
| Cd36 | cd36 antigen | NM_031561.2 | 2.36 | 0.0001 |
| Fabp4 | fatty acid binding protein 4 | XM_579554.1 | 2.09 | 0.0005 |
| Rora-repressed genes | up in DA | |||
| Mmp3 | matrix metallopeptidase 3 | NM_133523.2 | 12.81 | 0.002 |
| Timp1 | tissue inhibitor of metalloproteinase 1 | NM_053819.1 | 5.92 | 0.0002 |
| Cyp7b1 | cytochrome P450, 7b1 | NM_019138.1 | 3.59 | 0.003 |
| Ltb | lymphotoxin B | NM_212507.2 | 3.34 | 0.01 |
| Aif1 | allograft inflammatory factor 1 | NM_017196.3 | 3.07 | 0.000001 |
| Ucp2 | uncoupling protein 2 | NM_019354.2 | 2.68 | 0.00000004 |
| Stat2 | signal transducer and activator of transcription 2 | NM_001011905 | 2.46 | 0.0003 |
| Adrp | adipose differentiation-related protein | NM_001007144 | 2.25 | 0.00008 |
| Ctsk | cathepsin K | NM_031560.2 | 1.57 | 0.005 |
| Adam8 | a disintegrin and metalloprotease domain 8 | XM_574584.3 | 1.50 | 0.00007 |
| Lxra-induced genes (selected from a list of 24) | up in Cia25 | |||
| Thrsp | thyroid hormone responsive SPOT14 homolog | NM_012703.2 | 6.00 | 0.000005 |
| Slc2a4 | solute carrier family 2, member 4 (Glut4) | NM_012751.1 | 5.92 | 0.0000004 |
| Scd1 | stearoyl-Coenzyme A desaturase 1 | NM_139192.1 | 5.25 | 0.0001 |
| Pxmp2 | peroxisomal membrane protein | NM_031587.1 | 4.89 | 0.000003 |
| Pparg | nuclear receptor subfamily 1 (Nr1c3) | NM_013124.1 | 4.59 | 0.000005 |
| Srebf1 | sterol regulatory element binding factor 1 | XM_213329.3 | 4.34 | 0.000001 |
| Rev-erba | nuclear receptor subfamily 1 (Nr1d1) | NM_145775.1 | 4.11 | 0.0003 |
| Gstt1 | glutathione s transferase, theta 1 | NM_053293.2 | 3.53 | 0.000001 |
| Cd36 | cd36 antigen | NM_031561.2 | 2.36 | 0.0001 |
| Lxra | liver X receptor alpha, (Nr1h3) | NM_031627 | 1.60 | 0.002 |
| Lxra-repressed genes | up in DA | |||
| IL1b | interleukin-1 beta | NM_031512.2 | 7.40 | 0.004 |
| Ccl2 | c-chemokine ligand 2 | NM_031530.1 | 6.96 | 0.006 |
| Cyp7b1 | Cytochrome P450, 7b1 | NM_019138.1 | 3.59 | 0.003 |
| Pfkl | phosphofructokinase, liver, B-type | NM_013190.4 | 2.42 | 0.002 |
| Ppib | peptidylprolyl isomerase B (cyclophilin B) | NM_022536.1 | 1.75 | 0.00001 |
| Ahr | aryl hydrocarbon receptor | NM_013149.2 | 1.64 | 0.01 |
| Anxa2 | annexin A2 | NM_019905.1 | 1.58 | 0.0008 |
| Dnajc3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | NM_022232.1 | 1.56 | 0.00005 |
| Vdr-induced genes | up in Cia25 | |||
| Rxrg | retinoid X receptor gamma (Nr2b3) | NM_031765.1 | 3.15 | 0.00002 |
| Thbd | thrombomodulin | NM_031771.2 | 2.67 | 0.00003 |
| Txnip | thioredoxin interacting protein | NM_001008767 | 2.35 | 0.000001 |
| Fabp4 | fatty acid binding protein 4 | XM_579554.1 | 2.09 | 0.0005 |
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | NM_031762.3 | 1.99 | 0.0001 |
| Gucy1b3 | guanylate cyclase 1, soluble, beta 3 | NM_012769.2 | 1.91 | 0.0008 |
| Tjp1 | tight junction protein 1 | NM_001106266 | 1.84 | 0.00002 |
| Polr2f | polymerase (RNA) II (DNA directed) polypeptide F | NM_031335.3 | 1.57 | 0.00008 |
| Vdr-repressed genes (selected from list of 20) | up in DA | |||
| Prc1 | protein regulator of cytokinesis 1 | NM_001107529 | 26.34 | 0.00005 |
| Pole2 | polymerase (DNA directed), epsilon 2 (p59 subunit) | NM_001169108 | 7.75 | 0.000001 |
| Cdca8 | cell division cycle associated 8 | NM_001025050 | 6.90 | 0.0003 |
| Rs21c6 | replication factor C (activator 1) 3 | NM_001009629 | 4.89 | 0.00002 |
| Myo5a | myosin Va | NM_022178.1 | 3.84 | 0.0006 |
| Smc2 | structural maintenance of chromosomes 2 | NM_001108666 | 3.23 | 0.0006 |
| Rfc3 | replication factor C (activator 1) 3 | NM_001009629 | 3.03 | 0.00007 |
| Kif22 | kinesin family, member 22 | NM_001009645 | 2.73 | 0.00009 |
| Rarres1 | retinoic acid receptor responder (tazarotene induced) | NM_001014790 | 2.45 | 0.004 |
| Tgfb1 | transforming growth factor beta 1 | NM_021578.2 | 1.95 | 0.001 |
§
Sections ordered according to fold-difference;
*
t-test;
¶
gren font=up-regulated in Cia25 congenics and red font=up-regulated in DA synovium.