. Author manuscript; available in PMC: 2012 Nov 1.

Published in final edited form as: Pharmacol Biochem Behav. 2011 Aug 7;100(1):130–137. doi: 10.1016/j.pbb.2011.08.002

Table 5.

Anxiety-related behaviors (Mean ± SEM) of diestrous virgin and postpartum female rats tested in a light-dark box after IP injection of vehicle or PTZ.

	Virgin			Postpartum			Significant Effects
	Vehicle (n = 12)	PTZ 10 mg (n = 10)	PTZ 20 mg (n = 12)	Vehicle (n = 14)	PTZ 10 mg (n = 14)	PTZ 20 mg (n = 12)
Frequency of chamber transitions^#	3 ± 1	3 ± 1	3 ± 1	12 ± 2^a	9 ± 1^a	2 ± 1^b	State, Dose, State x Dose
Frequency of rears/Time spent in light chamber^*	9 ± 4	8 ± 3	3 ± 2	15 ± 1	10 ± 2	6 ± 6	Dose
Frequency of stretches from dark to light^#	23 ± 4	16 ± 5	9 ± 2	29 ± 3	28 ± 2	9 ± 3	State, Dose
Latency to enter dark chamber (s) ^#	2 ± 1	4 ± 1	3 ± 2	1 ± 0	2 ± 1	1 ± 1	State
Latency to re-enter the light chamber (s) ^#	389 ± 76	429 ± 86	459 ± 66	114 ± 46	94 ± 22	492 ± 65	State, Dose

Includes responders only.

Not normally distributed so log-transformed prior to analysis. Non-transformed means ± SEM are shown in all cases. Statistical significance was indicated by p < 0.05. Groups with different superscript letters significantly differ, one-way ANOVA within reproductive state, p < 0.05. See text for additional statistical details.