Table 1.
Background data at presentation of 10 patients with visual loss due to tumor-related optic neuropathy.
| Pt. No. | Gender/age (year)* | Follow-up (months) | Laterality* | Tumor type | Symptoms (duration/months) | Signs |
|---|---|---|---|---|---|---|
| 1 | F/9.1 | 4+ | B | Post. fossa astrocytoma | Headache, diplopia (2 months) | Esotropia, papilledema |
| 2 | M/6.2 | 8 | B | Post. fossa meduloblastoma | Reduced vision, ataxia (2 months) | Reduced vision, papilledema |
| 3 | M/8 | 79 | B | Pineal germinoma | Headache, reduced vision, hearing loss (2 months) | Reduced vision, Abnl. EOM (Parinaud), papilledema |
| 4 | M/7.1 | 12 | B | Craniopharyngioma | Diplopia, falls (0.5 months) | Reduced vision, papilledema |
| 5 | M/5 | 75 | B | Craniopharyngioma | Headache | Reduced vision, papilledema |
| 6 | F/5 | 48 | B | Craniopharyngioma | Reduced vision, headache (3 months) | Reduced vision, exotropia, optic atrophy |
| 7 | F/2.5 | 45 | M | Craniopharyngioma | None | Reduced vision, esotropia, mono-nystagmus, papilledema |
| 8 | M/6 | 192 | M | Optic nerve glioma‡ | None (Strabismus since birth) | Reduced vision, VF hemianopia, optic atrophy |
| 9 | F/9 | 113 | M | Optic nerve glioma | Headache, proptosis, reduced vision (8 months) | Reduced vision, VF hemianopia, optic atrophy |
| 10 | F/12 | 26 | M | Optic nerve glioma | Proptosis (1 months) | Proptosis, reduced vision, swollen disk, CVO |
Two children were totally asymptomatic at diagnosis. Seven of the eight symptomatic children had ocular symptoms already at presentation for the underlying disease. These included blurred vision (n = 4) with “bumping into objects” (in patient 3), diplopia (n = 2), and proptosis (n = 2). The diagnosis of the tumor was made on routine examination in two patients, during neuroimaging for neurofibromatosis type 1 in one patient, and during evaluation for new-onset strabismus, noted by the parents, in one patient. CVO, central vein occlusion; EOM, extraocular movement; M, monocular; B, bilateral; VF, visual field. *At presentation; +Parents refused follow-up; ‡Neurofibromatosis.