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. Author manuscript; available in PMC: 2012 Oct 27.
Published in final edited form as: Neuroscience. 2011 Jun 22;194:282–290. doi: 10.1016/j.neuroscience.2011.06.047

Figure 3.

Figure 3

Dendritic branching on BLA pyramidal-like neurons. A. Tracings of Golgi-impregnated neurons in BLA from each experimental group. B. Results of Sholl analysis of dendritic branching in WT (US, n=8; CS, n=8) and Fmr1 KO (US, n=8; CS, n=8) mice. Each point represents the mean ± SEM branches on 40 dendrites (5 per animal) of each genotype. Results were analyzed by RM ANOVA with genotype (WT, KO), treatment (US, CS) and distance from the soma as factors and repeated measures on distance from the soma. Both the genotype × condition × distance from the soma (F(4.6,718)=1.803, P=0.116) interaction and the condition × distance from the soma (F(4.6,718)=2.255, P=0.053) interaction approached statistical significance. The genotype × distance from the soma (F(4.6,718)=6.593, P<0.0001) interaction was statistically significant. Because the three-way interaction approached statistical significance we probed for specific group differences at each distance point by means of post-hoc Bonferroni t-tests. Results are shown in the figure as follows:
  • *, p<0.05, **, p<0.01; statistically significant difference between WT-US and KO-US
  • §, p<0.05, §§, p<0.01; statistically significant difference between WT-US and KO-US
  • Inline graphic, p<0.05, Inline graphic, p<0.01; statistically significant difference between WT-US and WT-CS
  • Inline graphic, p<0.05; statistically significant difference between KO-US and KO-CS

C. Total dendrite length of pyramidal-like BLA cells in WT (US, n=8; CS, n=8) and Fmr1 KO (US, n=8; CS, n=8) mice. Each point represents the mean ± SEM branches on 40 dendrites (5 per animal) of each genotype. Data were analyzed by means of ANOVA with genotype (WT, KO) and treatment (US, CS) as factors. The genotype × treatment interaction (F(1, 156) = 2.935, p = 0.089) and the main effect of condition (F(1, 156) = 2.458, p = 0.119) approached statistical significance. The main effect of genotype (F(1, 156) = 48.209, p<0.001) was statistically significant. Pairwise comparisons indicate statistically significant differences between genotypes under either US or CS conditions (***, p≤0.001) and between CS and US conditions in WT mice (*, p≤0.05).

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