Table 2.

Drug concentrations in normal tissue

Sample1	Irinotecan Concentration	SN-38 Concentration
Concurrent schedule2	% change4
L. Intestine	−20	−61
S. Intestine	19	−0.3
Bone marrow	20	−54***
Kidneys	9	−10
Liver	10	−14
Sequential schedule3	% change
L. Intestine	38	72
S. Intestine	−19	67

¹Samples in concurrent schedule were taken 2h after treatments and 14d after treatment in the sequential schedule

²MSC (0.2 mg/mouse) + irinotecan (100mg/kg)

³MSC (0.2 mg/mouse/d) 7d prior to and then concurrently with irinotecan (100mg/kg × 2)

⁴Compared to untreated controls

^***p<0.001 when compared with other groups