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. Author manuscript; available in PMC: 2012 Oct 1.

Published in final edited form as: Toxicol Mech Methods. 2011 Aug 23;21(8):577–584. doi: 10.3109/15376516.2011.578170

p38 inhibitor, SB202190, reverses ziram-induced granzyme B decreases and the p44/42 inhibitor, PD98059, reverses ziram-induced perforin decreases in NK cells: A) levels of granzyme B in cells exposed to 2.5 µM ziram in the presence and absence of the p38 inhibitor, SB202190. Values are mean ± S.D. from three separate experiments using cells from different donors. * indicates significant difference compared to the cells treated with ziram in the presence of SB202190 (p<0.05). B) Blots from a representative experiment. C) levels of perforin in cells exposed to 2.5 µM ziram in the presence and absence of the p44/42 inhibitor, PD98059 . Values are mean ± S.D. from three separate experiments using cells from different donors. * indicates significant difference compared to the cells treated with ziram in the presence of PD98059 (p<0.05). D) Blots from a representative experiment.

p38 inhibitor, SB202190, reverses ziram-induced granzyme B decreases and the p44/42 inhibitor, PD98059, reverses ziram-induced perforin decreases in NK cells: A) levels of granzyme B in cells exposed to 2.5 µM ziram in the presence and absence of the p38 inhibitor, SB202190. Values are mean ± S.D. from three separate experiments using cells from different donors. * indicates significant difference compared to the cells treated with ziram in the presence of SB202190 (p<0.05). B) Blots from a representative experiment. C) levels of perforin in cells exposed to 2.5 µM ziram in the presence and absence of the p44/42 inhibitor, PD98059 . Values are mean ± S.D. from three separate experiments using cells from different donors. * indicates significant difference compared to the cells treated with ziram in the presence of PD98059 (p<0.05). D) Blots from a representative experiment.