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. Author manuscript; available in PMC: 2012 Oct 5.

Published in final edited form as: J Am Chem Soc. 2011 Sep 9;133(39):15686–15696. doi: 10.1021/ja2058583

Table 5.

Activity (EC₅₀) and Cytotoxicity (CC₅₀) in μM for Wild-Type and the Tyr181Cys Variant Strain of HIV-1^a

	WT		Y181C
Compd	EC₅₀	CC₅₀	EC₅₀	CC₅₀
1	0.002	0.23	NA	0.11
2	0.010	9.0	NA	11.0
17	0.048	1.2	0.25	0.98
19	0.032	1.1	0.16	0.98
20	0.012	1.1	0.032	0.82
31	0.011	42.0	12.5	20.0
35	0.021	1.8	0.25	2.2
36	0.0025	0.12	0.0049	0.073
37	0.0017	1.5	0.015	2.2
d4T	1.4	>100	0.64	>100
nevirapine	0.11	>100	NA	>100
efavirenz	0.002	15.0	0.010	>0.1
etravirine	0.001	11.0	0.008	>0.1
rilpivirine	0.0004^b	8.0^b	0.0013^b

^a

See footnotes in Table 2.

^b

From Ref. 7 using MT4 cells.