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. Author manuscript; available in PMC: 2012 Dec 9.
Published in final edited form as: J Chromatogr A. 2011 May 27;1218(49):8791–8798. doi: 10.1016/j.chroma.2011.05.067

Figure 4.

Figure 4

The numbering 1–732 indicates the approximate positions in the amino acid sequence of the human protein that define its functional domains. ‘CR’ refers to a charged region which serves as a flexible linker between the N-terminal and middle domains. The locations where various small molecules bind HSP90 (heat-shock protein of 90 kDa) and modulate its function are indicated. The biochemical functions of each domain are also shown. 17AAG, 17-allylaminogeldanamycin; GA, geldanamycin {Reprinted from Ref. 65}.