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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Pain. 2011 Jul 6;152(10):2267–2276. doi: 10.1016/j.pain.2011.06.002

Figure 2.

Figure 2

Effect of 5HT treatment on intracellular calcium accumulation in capsaicin-sensitive (A) and capsaicin-insensitive (C) cultured TG neurons reported as change from baseline (Δ). A representative time course of the effect of 5HT followed by capsaicin on calcium influx (B) reported as actual ratio. Also shown is the response to capsaicin following 5HT (D). Capsaicin-sensitive neurons were identified by a 60 sec application of 30 nM capsaicin following 3 min 5HT (10 nM – 100 µM) treatment. The lower dotted line illustrates the response to initial vehicle (Veh) treatment and the upper dotted line illustrates the response to veh/capsaicin (Cap). Data is presented as mean ± SEM change from vehicle baseline (n=37–76 cells per group). Asterisks denote significance at p<0.05 compared to vehicle.