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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Pain. 2011 Jul 6;152(10):2267–2276. doi: 10.1016/j.pain.2011.06.002

Figure 5.

Figure 5

Targeting peripheral 5HT receptors attenuates 5HT enhancement of capsaicin-induced CGRP release from cultured trigeminal neurons. Cultures were pretreated with various concentrations of sumatriptan (A), ketanserin (C) and granisetron (D) for 15 minutes followed by treatment with 5HT (100 µM) for 15 minutes prior to stimulation with 5HT+capsaicin (50 nM) for 15 minutes. Data is shown in concentration-response curves as mean±SEM percentage of basal (~10 fmol) levels (n=8–12 per group). Also shown is the effect of GR 55562 on sumatriptan-induced reduction in CGRP release compared to 5HT alone (B). Asterisk denotes significance at p<0.05 compared to capsaicin treatment (A,C,D) alone or 5HT pretreatment (B).