Figure 7.

Downregulation of cathepsin B and uPAR induces p27 expression in vivo. Stereotactic implantation of 4910 and 5310 (1 × 105) tumor cells was performed, and after one week, PBS (mock), SV or pCU was injected into the brain using an Alzet mini‐osmotic pump. Five animals per group were used. 30 days after implantation, the animals were sacrificed, the brains were removed and fixed, and paraffin sections were prepared. Immunohistochemical analysis of paraffin‐embedded tissue sections was carried out for cathepsin B, uPAR, Ki67 and p27 expression. Bar: 20 μm.