Table 3.

Relative risk [RR] and 95% confidence intervals [CI] of CHD according to Lipoprotein Lipase S447X genotype in the Nurses’ Health Study (NHS), the Health Professionals Follow Up Study (HPFS), and the Diet, Cancer and Health (DCH) study.^*

	MAF (%)†		N (cases/controls)			Relative risk
	Cases	Control	SS	SX	XX	SS	SX	XX	SX/XX
NHS	7.4	12.1	211/379	33/100	1/6	1.0 (ref)	0.57 (0.36–0.90)	0.31 (0.04–2.82)	0.56 (0.36–0.87)
HPFS	8.5	12.0	216/406	40/99	2/10	1.0 (ref)	0.73 (0.49–1.10)	0.37 (0.08–1.69)	0.70 (0.47–1.04)
DCH women	8.1	10.5	193/638	35/142	1/12	1.0 (ref)	1.02 (0.65–1.61)	0.38 (0.05–2.98)	0.97 (0.62–1.52)
DCH men	8.9	9.2	606/745	123/157	4/5	1.0 (ref)	0.89 (0.67–1.18)	1.14 (0.29–4.45)	0.89 (0.67–1.18)
Pooled‡						1.0 (ref)	0.77 (0.58–1.03)	0.53 (0.29–0.97)	0.74 (0.56–1.00)

^*Conditional logistic regression models were run in NHS and HPFS data (stratified by matching factors). Cox proportional hazard regression models in DCH. All models adjusted for age, smoking, alcohol intake, body mass index, and menopausal status among women.

^†Minor allele frequency

^‡Meta-analysis using random effects. P for tests of between study heterogeneity: SX: 0.7; XX: 0.13; dominant (SX/XX): 0.12.