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. 2011 Apr 6;21(11):2620–2638. doi: 10.1093/cercor/bhr048

Figure 8.

Figure 8.

Ca responses in Au1 neurons are primarily synaptically mediated. (A) LFP recordings in layer 5 in response to WM stimulation (4 × 40 Hz, 100 μA) before (Ctrl), during (K Acid), and after (Recov) synaptic blockade with 4 mM kynurenic acid. (B) Corresponding fluorescence traces from experiment illustrated in (A). Responses in all but 2 of these cells were blocked (asterisks), and the effect reversed within 20 min (right column). Traces at bottom illustrate neuropil response. (C) Summary data from 8 experiments using either kynurenic acid (n = 4) or 6-cyano-7-nitroquinoxaline-2,3-dione/(2R)-amino-5-phosphonovaleric acid (n = 4) to block excitatory synaptic transmission in response to WM stimulation (68 cells) and from 7 experiments using 6-cyano-7-nitroquinoxaline-2,3-dione/(2R)-amino-5-phosphonovaleric acid to block responses to V2L stimulation (28 cells). Error bars are SD. Horizontal lines are mean of sham analysis (dashed line, i.e., responses detection algorithm run on data segments in which no stimulus was applied) and sham mean + 2SD (solid line).