Table 1.
Intrahepatic cholangiocarcinoma patient characteristics (n = 4893)
| Variable | Missing, n (%) | |
|---|---|---|
| Male sex, n (%) | 2539 (51.9) | 0 (0) |
| White race, n (%) | 3936 (80.6) | 9 (0.2) |
| Age, years, median (IQR) | 68 (57–76) | 0 (0) |
| Diagnosis year, n (%) | 0 (0) | |
| 1988–1997 | 1265 (25.8) | |
| 1998–2003 | 1913 (39.1) | |
| 2004–2007 | 1715 (35.1) | |
| Grade, n (%) | 2778 (56.8) | |
| Well differentiated | 308 (14.6) | |
| Moderately differentiated | 863 (40.8) | |
| Poorly differentiated | 890 (42.1) | |
| Undifferentiated | 54 (2.6) | |
| Tumour size, cm, median (IQR) | 6.0 (3.8–9.0) | 2865 (58.6) |
| AJCC 7th edn stage, n (%) | 901 (18.4) | |
| Stage I | 939 (23.5) | |
| Stage II | 142 (3.6) | |
| Stage III | 712 (17.8) | |
| Stage IV | 2199 (55.1) | |
| T-stage, n (%) | 1788 (36.5) | |
| T1 | 1053 (33.9) | |
| T2a | 171 (5.5) | |
| T2b | 877 (28.2) | |
| T3 | 1004 (32.3) | |
| T4 | a | |
| N-stage (N0), n (%) | 1788 (74.8) | 2503 (51.1) |
| M-stage (M0), n (%) | 2632 (64.2) | 792 (16.2) |
| Histologic regional LN evaluation, n (%) | 658 (13.5) | 185 (3.8) |
| Radiation therapy, n (%) | 767 (16.0) | 89 (1.8) |
| Major liver resection, n (%) | 733 (15.1) | 35 (0.7) |
a
The AJCC Staging Manual, 7th edition, defines T4 as tumour with periductal invasion. Cases in the SEER registry did not document periductal invasion and therefore no T4 cases were recorded.
IQR, interquartile range; AJCC, American Joint Committee on Cancer; LN, lymph node.