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. Author manuscript; available in PMC: 2011 Oct 21.
Published in final edited form as: Semin Reprod Med. 2010 Apr 22;28(3):250–259. doi: 10.1055/s-0030-1251482

Figure 4.

Figure 4

(A) Real-time polymerase chain reaction measurement of selected estrogen-responsive genes expressed in human uterine leiomyoma (UtLM) cells and human uterine smooth muscle cells (UtSMC) treated with 0.3% dimethylsulfoxide (control) or 1 µg/mL of genistein (Gen) for 24 hours. (B) Gen-induced interactions between estrogen receptor (ER)α and insulin-like growth factor I receptor (IGF-IR) in human uterine LM cells were determined by using immunoprecipitation (IP) and immunoblotting (IB). The interaction between ERα and IGF-IR was inhibited by the estrogen antagonist ICI 182,780 (A, B: Reprinted, with permission, from Di X, Yu L, Moore AB, et al. A low concentration of genistein induces estrogen receptor-alpha and insulin-like factor-I receptor interactions and proliferation in uterine leiomyoma cells. Hum Reprod 2008;23(8):1873–1883.)