Table I. High probability novel epitopes.
Protein | HLA | Epitope | Number of individuals tested | Positive responses (%) |
---|---|---|---|---|
Gag | C*07:01 | EIYKRWIIL | 12 | 58 |
Gag | B*42 | EPIDKELYPL | 5 | 40 |
Pol | B*27:05 | KRKGGIGGY1 | 7 | 86 |
Pol | C*04:01 | FPQGKAREF | 6 | 50 |
Tat | A*32:01 | NCYCKQCCF | 6 | 50 |
Nef | A*03 | SVVGWPAVR | 19 | 58 |
Nef | C*08 | QVPVRPMTYK | 11 | 55 |
Nef | B*14:02 | QRQDILDLW | 6 | 50 |
Nef | C*04:01 | VRYPLTFGW | 19 | 42 |
High probability novel epitopes were those for which the sequence or the HLA-restriction was not published as at 2009 LANL update; were tested in five or more individuals and had a positive response rate of greater than 40%.
This epitope was not listed in the January 2009 update of A or B-list epitopes but has been described in reference 28.