Table 3.
Gene expression level of candidate biomarkers of nephrotoxicity in the kidney of seven-week-old control (untreated) male and female F344 rats. Data are expressed as % Gapdh, except Gapdh, which is expressed as cycle threshold (Ct) value (mean ± SD).
| Gene | Females (F) | Males (M) | Fold-expression ratio (F/M) |
|---|---|---|---|
| Kim-1/Havcr1 | 1.21 ± 0.52 | 0.04 ± 0.01 | 34.53 * |
| Timp1 | 2.09 ± 0.51 | 0.94 ± 0.15 | 2.22 * |
| Clu | 10.79 ± 2.23 | 4.73 ± 1.39 | 2.28 * |
| Lcn2 | 0.02 ± 0.01 | 0.01 ± 0.00 | 2.28 * |
| Spp1 | 49.28 ± 17.97 | 9.45 ± 2.42 | 5.21 * |
| Gapdh | 22.97 ± 0.36 | 22.70 ± 0.56 | 1.01 |
*
indicates a significant difference between males and females (p-value < 0.05, t-test).