Table 5.
Paired attributable fractional difference induced by Plasmodium falciparum infection at days 0 and 28 in randomized controlled trials for convalescent-phase patients with uncomplicated Plasmodium falciparum malaria, sub-Saharan Africa*
| Parameter | No. | Day 28 | Day 0 | Paired fractional difference | Paired difference | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | % | Lower 95% CI | Upper 95% CI | Mean | SD | P | ||
| Leukocytes (×109 cells/L) | 1,157 | 9.0 | 3.8 | 9.5 | 4.4 | 5 | 3 | 8 | 0.5 | 4.1 | 0.001 |
| Neutrophils (×109 cells/L) | 1,061 | 3.0 | 1.7 | 4.2 | 2.8 | 43 | 37 | 50 | 1.3 | 3 | 0.001 |
| Lymphocytes (×109 cells/L) | 768 | 6.1 | 3.1 | 5.1 | 3.3 | −16 | −20 | −11 | −0.9 | 3.5 | 0.001 |
| Hemoglobin (g/dL) | 1,642 | 9.4 | 2.4 | 8.2 | 2.7 | −13 | −14 | −11 | −1.2 | 1.5 | 0.001 |
| Platelets (×109 cells/L) | 459 | 338 | 163 | 172 | 102 | −49 | −50 | −48 | −165 | 174 | 0.001 |
*
CI = confidence interval.