Table 5.

Geometric mean titers and seropositivity (percent with titer ≥ 10) to at least one, two, three, or all four serotypes before and up to 180 days after a single injection of tetravalent dengue vaccine

	VDV-primed (N = 15)				YF-primed (N = 8)				Naive (N = 12)
	D0	D28	D60	D180	D0	D28	D60	D180	D0	D28	D60	D180
Seropositive to ≥ 1 serotype
n	11	15	15	15	1	8	8	8	0	11	11	11
%	73	100	100	100	13	100	100	100	0	92	92	92
95% CI	45–92	78–100	78–100	78–100	0–53	63–100	63–100	63–100	0–27	62–100	62–100	62–100
Seropositive to ≥ 2 serotypes
n	0	15	14	12	0	7	7	7	0	5	6	7
%	0	100	93	80	0	88	88	88	0	42	50	58
95% CI	0–22	78–100	68–100	52–96	0–37	47–100	47–100	47–100	0–27	15–72	21–79	27–85
Seropositive to ≥ 3 serotypes
n	0	11	10	8	0	6	7	7	0	2	1	1
%	0	73	67	53	0	75	88	88	0	17	8	8
95% CI	0–22	45–92	38–88	27–79	0–37	35–97	47–100	47–100	0–27	2–48	0–39	0–39
Seropositive to all serotypes
n	0	10	8	7	0	2	3	5	0	0	1	1
%	0	67	53	47	0	25	38	63	0	0	8	8
95% CI	0–22	38–88	27–79	21–73	0–37	3–65	9–76	25–92	0–27	0–27	0–39	0–39
Geometric mean titer
GMT DENV-1	7.02	45.8	39.1	27.2	5.00	8.40	14.9	13.4	5.00	5.00	5.38	6.19
95% CI	4.70–10.5	28.5–73.8	25.0–61.2	16.4–45.0	5.00–5.00	3.76–18.8	6.47–34.1	7.45–24.1	5.00–5.00	5.00–5.00	4.58–6.32	4.51–8.49
GMT DENV-2	13.4	52.5	50.8	41.8	5.74	28.1	29.7	25.4	5.00	7.67	11.9	13.1
95% CI	7.04–25.7	21.8–126	20.3–127	16.8–104	4.15–7.94	10.8–73.1	10.1–87.2	8.44–76.3	5.00–5.00	4.62–12.7	6.38–22.0	6.74–25.5
GMT DENV-3	5.36	41.4	17.9	15.2	5.00	33.1	22.4	27.6	5.00	28.0	16.3	13.3
95% CI	4.62–6.20	20.6–83.1	9.37–34.4	8.25–28.1	5.00–5.00	13.9–78.7	8.05–62.6	12.5–60.9	5.00–5.00	8.95–87.2	5.99–44.5	5.76–30.6
GMT DENV-4	5.00	91.1	77.3	42.5	5.00	221	155	124	5.00	103	44.0	33.2
95% CI	5.00–5.00	37.5–222	34.5–173	18.3–98.6	5.00–5.00	64.4–762	58.6–411	54.1–286	5.00–5.00	20.0–527	11.5–169	11.1–99.8