Figure 7.

Eigenvectors with the first (A and B) and fourth (C and D) largest eigenvalues of the correlation matrices from ATP-bound and ATP-free complexes mapped onto the corresponding structures. The intensity of the color represents the coefficient (χ_i) of residue motion i to each eigenvector. Blue/green versus red/orange correspond to combinations with opposite phase (sign is arbitrary). (E) Structure of human MSH2-MSH6 showing colon-cancer-linked mutations that map by structural alignment (23) to Taq MutS residues in clusters from eigenvector 1 (shown in A and B).