Demographic models considered for demographic inference. The left image depicts the isolation model, with parameters ancestral effective size (NANC), outgroup size (NOUTG), European (NEUR) and Asian (4Nμ) effective sizes, speciation time (TOUTG) and split time between Asian and European populations (TANC). In addition, the isolation plus migration model (on the right) allows for unidirectional migration from Asia to Europe at a scaled rate MA → E.