Table 1.

Equilibrium folding parameters of C^thermo and C^meso

Parameter	Cthermo	Cmeso
I-to-N transition
Mg2+ Hill coefficient (n)	7.8  ± 0.3	2.9  ± 0.4*
Surface burial (m, kcal mol−1M−1)	3.8  ± 0.2	1.0  ± 0.1*
Heat capacity (ΔCp, kcal mol−1K−1)	2.5  ± 0.3	0.46  ± 0.12
Transition midpoint (KMg, mM, 37°C)	0.11  ± 0.01	1.2  ± 0.2*
Hypochromicity at 260 nm	ΔAbsthermo > ΔAbsmeso
I state structure
Radius of gyration (Rg, Å)	60  ± 1	46  ± 1†
N state structure
Radius of gyration (Rg, Å)	37.6  ± 0.5	38.0  ± 0.5†
Hydroxyl radical footprinting	Cthermo ≈ Cmeso

^*C^meso data from ref. 25. 

^† C^meso data from ref. 23.