Skip to main content
. 2011 Sep 28;52(10):7593–7602. doi: 10.1167/iovs.11-7510

Table 7.

Replication Results in European Samples

ARIC
CHS
MESA
AGES
BMES
FIND-Eye
FinnDiane
Go-DARTS
Lublin
Meta-analysis (Fixed Effects)
Controls, n
732
160
140
249
175
627
570
774
620
Cases ETDRS ≥14, n
153
33
36
92
67
105
2009
923
576
Cases ETDRS ≥30, n
91
20
11
37
26
NA
1399
923
138
SNP Minor Allele Definition of Cases OR P OR P OR P MAF OR P MAF OR P MAF OR P MAF OR P MAF OR P MAF OR P z Score OR P
rs9332570 G ETDRS ≥14 0.43 0.0001 0.33 0.02 0.49 0.06 NA 0.75 0.26 0.21 1.24 0.42 0.19 0.79 0.26 0.27 1.16 0.05 NA NA NA NA NA NA 0.002 1 0.99
rs35260 A ETDRS ≥14 0.68 0.002 0.59 0.08 0.29 0.0001 NA 1.01 0.98 0.49 1.23 0.32 0.48 0.9 0.45 0.5 0.96 0.59 0.44 0.98 0.77 NA NA NA −2.24 0.91 0.03
rs6128 T ETDRS ≥14 0.48 0.0007 0.27 0.02 0.39 0.03 0.09 1.27 0.32 0.21 1.27 0.37 0.17 0.73 0.14 0.24 1.16 0.07 NA 1.13 0.21 0.16 1.01 0.96 0.6 1.03 0.55
rs7168655 A ETDRS ≥14 1.59 0.0004 1.78 0.04 1.48 0.15 NA 0.91 0.57 0.34 0.96 0.83 0.36 1.08 0.63 0.34 1.02 0.82 0.34 0.96 0.6 NA NA NA 1.55 1.07 0.12
rs6133 A ETDRS ≥14 0.39 0.0005 0.19 0.03 0.51 0.16 0.15 0.73 0.32 0.14 1.37 0.28 0.13 0.72 0.17 0.09 1.13 0.31 NA 1.08 0.45 0.08 1.03 0.84 −0.42 0.98 0.68
rs3917779 A ETDRS ≥14 0.40 0.0007 0.20 0.03 0.51 0.16 0.09 0.73 0.32 0.14 1.25 0.45 0.12 0.72 0.19 0.09 1.14 0.29 NA NA NA NA NA NA −1.39 0.88 0.17
rs6856425 C ETDRS ≥14 2.48 0.01 5.21 0.004 2.63 0.16 0.04 0.89 0.86 0.02 1.8 0.45 0.02 1.18 0.75 0.03 0.97 0.87 0.02 1.34 0.27 0.05 0.7 0.07 1.1 1.13 0.27
rs7105871 C ETDRS ≥14 0.47 1.7 × 10−5 0.97 0.91 0.86 0.62 NA 0.81 0.2 0.25 1.16 0.54 0.22 0.88 0.47 0.31 1 0.96 NA NA NA NA NA NA −1.85 0.9 0.07
rs6856425 C ETDRS ≥30 3.19 0.003 6.8 0.002 3.25 0.19 NA NA NA NA NA NA NA NA NA 0.03 0.79 0.39 0.02 1.34 0.27 0.05 0.46 0.06 1.65 1.28 0.1

All results are adjusted for age and sex. NA, not available.