Table 7.
ARIC |
CHS |
MESA |
AGES |
BMES |
FIND-Eye |
FinnDiane |
Go-DARTS |
Lublin |
Meta-analysis (Fixed Effects) |
||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Controls, n |
732 |
160 |
140 |
249 |
175 |
627 |
570 |
774 |
620 |
||||||||||||||||||||
Cases ETDRS ≥14, n |
153 |
33 |
36 |
92 |
67 |
105 |
2009 |
923 |
576 |
||||||||||||||||||||
Cases ETDRS ≥30, n |
91 |
20 |
11 |
37 |
26 |
NA |
1399 |
923 |
138 |
||||||||||||||||||||
SNP | Minor Allele | Definition of Cases | OR | P | OR | P | OR | P | MAF | OR | P | MAF | OR | P | MAF | OR | P | MAF | OR | P | MAF | OR | P | MAF | OR | P | z Score | OR | P |
rs9332570 | G | ETDRS ≥14 | 0.43 | 0.0001 | 0.33 | 0.02 | 0.49 | 0.06 | NA | 0.75 | 0.26 | 0.21 | 1.24 | 0.42 | 0.19 | 0.79 | 0.26 | 0.27 | 1.16 | 0.05 | NA | NA | NA | NA | NA | NA | 0.002 | 1 | 0.99 |
rs35260 | A | ETDRS ≥14 | 0.68 | 0.002 | 0.59 | 0.08 | 0.29 | 0.0001 | NA | 1.01 | 0.98 | 0.49 | 1.23 | 0.32 | 0.48 | 0.9 | 0.45 | 0.5 | 0.96 | 0.59 | 0.44 | 0.98 | 0.77 | NA | NA | NA | −2.24 | 0.91 | 0.03 |
rs6128 | T | ETDRS ≥14 | 0.48 | 0.0007 | 0.27 | 0.02 | 0.39 | 0.03 | 0.09 | 1.27 | 0.32 | 0.21 | 1.27 | 0.37 | 0.17 | 0.73 | 0.14 | 0.24 | 1.16 | 0.07 | NA | 1.13 | 0.21 | 0.16 | 1.01 | 0.96 | 0.6 | 1.03 | 0.55 |
rs7168655 | A | ETDRS ≥14 | 1.59 | 0.0004 | 1.78 | 0.04 | 1.48 | 0.15 | NA | 0.91 | 0.57 | 0.34 | 0.96 | 0.83 | 0.36 | 1.08 | 0.63 | 0.34 | 1.02 | 0.82 | 0.34 | 0.96 | 0.6 | NA | NA | NA | 1.55 | 1.07 | 0.12 |
rs6133 | A | ETDRS ≥14 | 0.39 | 0.0005 | 0.19 | 0.03 | 0.51 | 0.16 | 0.15 | 0.73 | 0.32 | 0.14 | 1.37 | 0.28 | 0.13 | 0.72 | 0.17 | 0.09 | 1.13 | 0.31 | NA | 1.08 | 0.45 | 0.08 | 1.03 | 0.84 | −0.42 | 0.98 | 0.68 |
rs3917779 | A | ETDRS ≥14 | 0.40 | 0.0007 | 0.20 | 0.03 | 0.51 | 0.16 | 0.09 | 0.73 | 0.32 | 0.14 | 1.25 | 0.45 | 0.12 | 0.72 | 0.19 | 0.09 | 1.14 | 0.29 | NA | NA | NA | NA | NA | NA | −1.39 | 0.88 | 0.17 |
rs6856425 | C | ETDRS ≥14 | 2.48 | 0.01 | 5.21 | 0.004 | 2.63 | 0.16 | 0.04 | 0.89 | 0.86 | 0.02 | 1.8 | 0.45 | 0.02 | 1.18 | 0.75 | 0.03 | 0.97 | 0.87 | 0.02 | 1.34 | 0.27 | 0.05 | 0.7 | 0.07 | 1.1 | 1.13 | 0.27 |
rs7105871 | C | ETDRS ≥14 | 0.47 | 1.7 × 10−5 | 0.97 | 0.91 | 0.86 | 0.62 | NA | 0.81 | 0.2 | 0.25 | 1.16 | 0.54 | 0.22 | 0.88 | 0.47 | 0.31 | 1 | 0.96 | NA | NA | NA | NA | NA | NA | −1.85 | 0.9 | 0.07 |
rs6856425 | C | ETDRS ≥30 | 3.19 | 0.003 | 6.8 | 0.002 | 3.25 | 0.19 | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.03 | 0.79 | 0.39 | 0.02 | 1.34 | 0.27 | 0.05 | 0.46 | 0.06 | 1.65 | 1.28 | 0.1 |
All results are adjusted for age and sex. NA, not available.