Table 3.
Sensitivity and Specificity Analysis Results
| Feature | Measurement Parameters |
|||||
|---|---|---|---|---|---|---|
| B-Scan Count | A-Scan Count | Maximum Height | FCS Thickness (>7 μm) | FCS Thickness (>100 μm) | Macular Volume | |
| CME | ||||||
| Sensitivity, % | 100.0 | 100.0 | 100.0 | 75.0 | 0.0 | 100.0 |
| Specificity, % | 100.0 | 100.0 | 100.0 | 18.2 | 81.8 | 0.0 |
| SRF | ||||||
| Sensitivity, % | 100.0 | 91.7 | 100.0 | 91.7 | 16.7 | 100.0 |
| Specificity, % | 85.7 | 66.7 | 71.4 | 42.9 | 100.0 | 0.0 |
| PED | ||||||
| Sensitivity, % | 66.7 | 100.0 | 66.7 | 66.7 | 0.0 | 66.7 |
| Specificity, % | 56.3 | 31.3 | 18.8 | 25.0 | 87.5 | 0.0 |
| CME and SRF* | ||||||
| Sensitivity, % | 100.0 | 100.0 | 100.0 | 81.3 | 12.5 | 100.0 |
| Specificity, % | 66.7 | 33.3 | 33.3 | 33.3 | 100.0 | 0.0 |
The results show that the simplified parameters are both sensitive and specific for a detection of change in CME or SRF volume. FCS thickness, a parameter used in clinical trials, has a sensitivity of only 81.3% for detecting a change in either intra- or subretinal fluid (CME and SRF), although a cutoff of only 7 μm was used in this analysis.
*
CME and SRF were treated as a single feature in this group.