FIGURE 1.

DM^−/− and DM^−/−Ii^−/− BALB/c mice are resistant to FP infection with L. major. BALB/c/J, DM^−/−, Ii^−/−, and DM^−/−Ii^−/− were infected in one hind FP with 0.5 × 10⁶ metacyclic promastigote L. major parasites. Twelve to 18 age-matched female (two experiments) or male and female (three experiments) mice were used for each group. The thickness and diameter of the FP was measured each week postinfection. Closed symbols represent the sizes of the infected FP and the open symbols represent sizes of the uninfected foot pads. Note that the lesion size in the wild-type and Ii^−/− mice continued to grow and these mice had to be euthanized (E) by day 84. In contrast, the DM^−/− and DM^−/−Ii^−/− mice developed minimal lesions and the FP size of these mice was measured until day 105 postinfection. Note that in our experience the time point at which the wild-type mice reached maximal FP lesions varied between week 6 and 12 in different experiments. Mice infected with 2.0 × 10⁶ parasites showed the same results.